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2025-26 Men’s Final Four Odds: Duke, Michigan, Florida and Arizona Favored

cudhfrance@gmail.com by cudhfrance@gmail.com
March 21, 2026
in Sports
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2025-26 Men’s Final Four Odds: Duke, Michigan, Florida and Arizona Favored



The men’s Final Four isn’t necessarily close, but it’s not far either. 

Who is favored to be one of the last teams standing?

Let’s check out the odds for the 2026 Final Four at DraftKings Sportsbook as of March 21. 

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

To reach the Final Four 2026

East Region

Duke: -120 (bet $10 to win $18.33 total)
UConn: +650 (bet $10 to win $75 total)
Michigan State: +750 (bet $10 to win $85 total)
St. John’s: +800 (bet $10 to win $90 total)
Kansas: +1500 (bet $10 to win $160 total)
Louisville: +1700 (bet $10 to win $180 total)
UCLA: +2200 (bet $10 to win $230 total)
TCU: +7500 (bet $10 to win $760 total)

Midwest Region

Michigan: -135 (bet $10 to win $17.41 total)
Iowa State: +425 (bet $10 to win $52.50 total)
Tennessee: +1000 (bet $10 to win $110 total)
Virginia: +1100 (bet $10 to win $120 total)
Texas Tech: +1500 (bet $10 to win $160 total)
Alabama: +2000 (bet $10 to win $210 total)
Kentucky: +3000 (bet $10 to win $310 total)
Saint Louis: +6500 (bet $10 to win $660 total)

South Region

Florida: +180 (bet $10 to win $28 total)
Houston: +225 (bet $10 to win $32.50 total)
Illinois: +350 (bet $10 to win $45 total)
Nebraska: +1100 (bet $10 to win $120 total)
Vanderbilt: +1300 (bet $10 to win $140 total)
Iowa: +4500 (bet $10 to win $460 total)
VCU: +7500 (bet $10 to win $760 total)
Texas A&M: +8000 (bet $10 to win $810 total)

West Region

Arizona: -120 (bet $10 to win $18.33 total)
Purdue: +350 (bet $10 to win $45 total)
Gonzaga: +600 (bet $10 to win $70 total)
Arkansas: +750 (bet $10 to win $85 total)
Miami FL: +4500 (bet $10 to win $460 total)
Texas: +5000 (bet $10 to win $510 total)
Utah State: +6000 (bet $10 to win $610 total)
High Point: +40000 (bet $10 to win $4,010 total)

Here’s what to know about the Final Four oddsboard: 

The Favorite(s): Duke, Arizona, Michigan and Florida are favored to comprise the Final Four — all four No. 1 seeds. Arizona last made the Final Four way back in 2001, while Michigan last made it in 2018. The Blue Devils last made a Final Four appearance last season, and the Gators are the defending champions. In terms of current form, the Blue Devils did not impress in the first round, while Arizona, Michigan and Florida won in convincing fashion.

The Contenders: UConn, Iowa State, Houston and Purdue are the four teams expected to challenge the favorites in each region, at least according to the odds. The Huskies have won two of the last three national titles (2023 and 2024) and lost to eventual national champion Florida by two in the second round of last season’s NCAA Tournament. In the first round, UConn eked past Furman, while ISU, Houston and Purdue each pulled off 30-point wins. 

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